MedGenome is driven to enable clinicians to deliver the best outcomes to their patients. Our passion to deliver actionable insights to clinicians has resulted in the development of “Claria” - a suite of NGS (Next-Generation Sequencing) technology-based solutions for reproductive testing. Claria offers the most accurate Non-Invasive Prenatal Screening Test (NIPT), the Genetic Carrier Screening Test and the Preimplantation Genetic Screening/Diagnosis (PGS/PGD).
In addition to this Claria now offers not just advanced NGS based tests but also routine prenatal diagnostics and cytogenetic tests
# McCoy RC. Mosaicism in Preimplantation Human Embryos: When chromosomal abnormalities are the norm. Trends Genet. 33(7): 448–463 (2017).
* Harton GL, Munne S, Surrey M, et al. Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization. Fertil Steril. 2013;100(6):1695–1703.
A biopsy can be done on Day 3 (Blastomere) or Day 5 (Trophectoderm).
On Day 3, a fresh embryo transfer is possible. However, on Day 5,a frozen embryo transfer is possible, which is why Day 5 biopsy is recommended.
MedGenome’s PGS test has shown 100% accuracy in Aneuploidy detection, when external validation was done using Proficiency Testing (PT) samples by the American Association of Bioanalysts.
|Fluorescent In Situ Hybridisation (FISH)||Array Comparative Genomic Hybridisation (aCGH)||Single Nucleotide Polymorphism (SNP) Microarray||NGS|
|A largely manual process, highly skill/ operator dependant.||Requires normal DNA for each sample to provide a comparison. A prolonged hybridisation step.||SNP array analysis of DNA, extracted from a cell population, cannot indicate the mosaicism within the sample.||NGS detects partial chromosomal gains and losses more precisely. NGS detects Aneuploidy and segmental imbalances at the same time.|
|Screening all 24 chromosomes at once requires a special probes set, requiring separate software at higher cost per sample.||Levels of mosaicism of 20% or less will not be detected.||Longer time needed to complete intended test.||NGS provides more accurate detection of mosaicism of the Trophectoderm cells from blastocyst biopsy.|
|Difficult to resolve chromosomal overlaps/ split signals.||Relatively expensive.||Relatively expensive.||NGS offers reduced costs and enhanced precision. It allows parallel analysis for multiple embryos for a single patient. In a single run, samples from different patients can be analysed together as well.|
PGD is a diagnostic procedure to test the material collected from an embryo for the presence of mutations carried by one or both parents. This is carried out when one or both genetic parents has a known genetic abnormality. In PGD every test is prepared on a case-by-case basis.
MedGenome Labs Pvt. Ltd.,
(At least 2 days in advance)
Our representative will get in touch with you within 24 hours to help you with the registration. You can start prescribing the test right away and help your patients gain clarity about their genetic health.