Claria From MedGenome

MedGenome is driven to enable clinicians to deliver the best outcomes to their patients. Our passion to deliver actionable insights to clinicians has resulted in the development of “Claria” - a suite of NGS (Next-Generation Sequencing) technology-based solutions for reproductive testing. Claria offers the most accurate Non-Invasive Prenatal Screening Test (NIPT), the Genetic Carrier Screening Test and the Preimplantation Genetic Screening/Diagnosis (PGS/PGD).

In addition to this Claria now offers not just advanced NGS based tests but also routine prenatal diagnostics and cytogenetic tests

What is Product of Conception testing?

The etiology of abortion is multifactorial and may involve endocrine, anatomic, immunological, infectious, environmental and genetic factors. About 60% of pregnancy losses are due to chromosomal abnormalaties. POC testing can detect whether the pregnancy had an abnormal chromosome number (aneuploidy) that might have caused a miscarriage. The information from POC testing can be helpful for patients and physicians to understand the cause of miscarriage and to develop a plan to support a future successful pregnancy.

Who should undergo POC testing?
  • Any couple who have a pregnancy loss with fetal abnormalities being detected
  • Couples who have had a miscarriage
  • Couples with recurrent pregnancy loss
  • Couples undergoing IVF who have have repeated implantation failure
How is POC testing done?

POC testing was done earlier using Karyotyping and FISH, however these methods had several limitations such as requiring large number of cells and cell culture. Recently POC testing is being performed using molecular tests such as Chromosomal Microarray and Next Generation Sequencing.

What technology does Claria POC test use?

Claria POC testing is done using the Affymetrix Optima Chromosomal Microarray (CMA).

Why choose the Claria POC testing?
  • No cell culture is necessary
  • Highly sensitive platform with >99% sensitivity for detection of chromosomal deletion/ duplications
  • The array has whole genome coverage and increase coverage targeting 396 regions relevant for prenatal analysis (18,018 CNV and 148,450 SNP)
  • Increased coverage density (25 markers/100 kb) in 396 empirically selected regions relevant for prenatal research
  • It can detect low levels of Mosaicism in the sample
  • A minimum resolution of 1 MB for losses, 2 MB for gains, and 5 MB for LOH/AOH (Loss/Absence of Heterozygosity)

Talk to our genetic experts for free today or reach us

Our certified genetic specialists are available right now to discuss your queries before, during and after screenings.

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