Coronary Artery Disease (CAD) is a heart condition that causes blockages in the arteries of the heart due to deposition of plaque preventing oxygenated blood supply to the heart. This causes heart attack/angina/MI, all of which can be fatal.
Genetic research over the past decade has realized that our risk for many common conditions such as heart disease and diabetes are not influenced by just one gene, or even a handful of them. Instead, multiple genes work in tandem to influence our risk for diseases.
Many small-effect genetic variations contribute to a person’s susceptibility to CAD. Polygenic Risk Score (PRS) prediction quantifies the contributing effects into a score and estimates whether the tested individual is at a high and average risk of CAD.
A genome-wide PRS for CAD integrates information from millions of sites of common DNA variation into a single metric-available from birth – of inherited risk.
CAD PRS is highly sensitive to picking up young onset CAD with ~90% positive predictive value4. This mean 90% of times the test was able to predict high risk for individuals who had a coronary event before 45 years of age.
Note: The KardioGen test is a screening test and hence all high risk individuals may not get a high risk score and several with average risk can get CAD early depending on other risk factors.
Existing risk predictions are based on factors such as weight, lifestyle, blood measurements and which are variable thought a person’s lifetime and cannot be used to predict risk accurately.
CAD PRS on the other had is an independent genetic predictor and is free from variabilities. The test is based on a person’s genetic makeup and predicts their risk profile.
Knowing a person’s risk can help in timely lifestyle changes, health monitoring and disease management.
Just 3 ml of your blood can give your CAD PRS score