Febrile Neutropenia Panel

Early detection of infections in immunocompromised patients

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What Is Febrile Neutropenia Panel?

Febrile neutropenia panel is a molecular diagnostic test designed to rapidly detect bacterial, viral, and fungal infections, along with antimicrobial resistance (AMR) genes, in immunocompromised patients. Utilising multiplex RT-PCR technology, this test provides high sensitivity and specificity, allowing for early identification of pathogens in cancer patients undergoing chemotherapy, transplant recipients, and neutropenic individuals. By enabling timely intervention and targeted antimicrobial therapy, the febrile neutropenia panel significantly reduces the risk of sepsis, organ damage, and mortality in high-risk patients.

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Target Coverage in the Febrile Neutropenia Panel

Category	Pathogens Detected
Gram-Positive Bacteria	Staphylococcus spp, Staphylococcus aureus, Streptococcus spp, Streptococcus pneumoniae, Enterococcus faecium, Enterococcus faecalis, Listeria monocytogenes.
Gram-Negative Bacteria	Neisseria meningitidis, Haemophilus influenzae, Pseudomonas spp, Pseudomonas aeruginosa, Klebsiella pneumoniae, Klebsiella oxytoca, Acinetobacter baumannii, Stenotrophomonas maltophilia, Escherichia coli, Enterobacteriaceae.
Antimicrobial Resistance (AMR) Genes	VanA (Vancomycin resistance), VanB (Vancomycin resistance), OXA-48 (Carbapenem resistance), KPC (Carbapenem resistance), NDM (Carbapenem resistance), VIM (Carbapenem resistance), IMP (Carbapenem resistance), mecA/mecC (Methicillin resistance).
Fungi	Candida krusei, Candida glabrata, Candida albicans, Candida parapsilosis, Candida tropicalis.
Viruses	Enterovirus, Epstein-Barr virus (EBV), Herpes Simplex virus 1 (HSV-1), Herpes Simplex virus 2 (HSV-2), Human Adenovirus, Human Cytomegalovirus (CMV), Human Herpesvirus 6 (HH6), Human Herpesvirus 7 (HH7), Human Parechovirus, Human Parvovirus B-19, Varicella Zoster Virus (VZV).

Clinical Applications of the Febrile Neutropenia Panel Test

Detects multiple pathogens and antimicrobial resistance (AMR) genes in a single test, guiding targeted therapy.
Helps prevent life-threatening complications like sepsis and multi-organ failure in high-risk patients.
Reduces unnecessary antibiotic use, supporting antimicrobial stewardship and preventing resistance.
Ideal for cancer patients undergoing chemotherapy, transplant recipients, and immunocompromised individuals who are at high risk of infections.
Ensures comprehensive infection monitoring in patients with febrile neutropenia, unexplained fevers, or bloodstream infections.

Specifications

Test Code: MGM3207
Methodology: Multiplex RT-PCR
Turnaround Time: 1 working day
Specimen Type: Whole blood
Container: EDTA tube
Transportation Temperature: 2-8°C
Volume Requirement: 3 ml
Storage Conditions: Transport at 2-8°C within 24 hours of collection. If transport is delayed beyond 24 hours, freeze at -20°C/-80°C and ship with dry ice.

Diseases & Disorders Detected by the Neutropenia Panel Test

Applicable for Diseases

Febrile neutropenia
Sepsis
Pneumonia
Bloodstream infections
Fungal and bacterial infections

Applicable for Disorders

Chemotherapy-induced neutropenia
Bone marrow suppression
Immunodeficiency syndromes
Hematological malignancies
Post-transplant immunosuppression

Key Highlights of MedGenome's Febrile Neutropenia Panel

Infection Detection for High-Risk Patients

Essential for cancer patients undergoing chemotherapy, transplant recipients, and individuals with weakened immune systems, reducing the risk of severe infections and complications.

Fast Turnaround Time for Early Treatment

Delivers results within a working day, enabling clinicians to initiate targeted antimicrobial therapy quickly and prevent progression to sepsis.

Reduces Hospital Stay & Unnecessary Antibiotic Use

Helps avoid broad-spectrum antibiotic overuse, supports antimicrobial stewardship, and minimises hospitalisation time and healthcare costs.

Genetic Counselling Support

Expert pre- and post-test genetic counselling is available to help clinicians and patients understand the respiratory PCR Panel test results and next steps.

What Is Febrile Neutropenia Panel?

Febrile neutropenia panel is a specialised blood test that helps identify infections in people with low white blood cell counts (neutropenia). Febrile neutropenia is a serious condition, especially in cancer patients undergoing chemotherapy, as their immune system is too weak to fight infections. This test detects bacteria, viruses, fungi, and antimicrobial resistance genes, helping doctors quickly diagnose the cause of fever and select the right treatment. Early detection with this test can help prevent severe complications and life-threatening infections.

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How Does Febrile Neutropenia Panel Differ From Other Blood Tests?

Feature	Febrile Neutropenia Panel	Regular Blood Tests
Purpose	Detects infections in immunocompromised patients.	Checks overall blood health and common infections.
Pathogens Detected	Bacteria, viruses, fungi, and antimicrobial resistance genes.	Mostly detects bacterial infections.
Target Group	Cancer patients, transplant recipients, and those with weakened immunity	General population
Methodology	Uses Multiplex RT-PCR technology for faster, more accurate results.	Often relies on culture-based methods, which take longer turnaround time.

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How Does Febrile Neutropenia Panel Work?

Febrile neutropenia panel works by analysing a small blood sample to check for infections. Using advanced molecular techniques, it detects the presence of bacteria, viruses, and fungi in the bloodstream.

Rapid Identification of Infections – The test detects infections within a few hours, allowing doctors to start treatment immediately.
Detection of Antimicrobial Resistance Genes – It identifies if bacteria are resistant to antibiotics, helping doctors choose the right medication.
Highly Accurate Testing – Uses multiplex RT-PCR technology, which is more precise than standard blood cultures.

This test ensures early diagnosis, helping doctors prevent infections from spreading in high-risk patients.

How Is The Febrile Neutropenia Panel Test Done?

MedGenome clinician reviewing patient records to support genetic testing and DNA test in India

Who Should Consider Febrile Neutropenia Testing?

Febrile neutropenia panel is recommended for:

Cancer patients undergoing chemotherapy, as they have a weakened immune system.
Patients with unexplained fever and low neutrophil counts.
Transplant recipients, who are more vulnerable to infections.
Individuals with weakened immunity due to long-term illness or medication.
People at high risk of bacterial or fungal bloodstream infections.

What Do Febrile Neutropenia Panel Test Results Indicate?

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When Should You Get A Febrile Neutropenia Panel Test?

The test should be taken immediately if a patient with a weakened immune system experiences:

Fever of 100.4°F (38°C) or higher, lasting more than an hour.
Chills, extreme fatigue, or rapid heartbeat.
Shortness of breath or chest pain.
Unexplained skin rashes or swelling.
Severe nausea, vomiting, or diarrhoea.

Delaying the test can lead to serious infections, organ damage, or sepsis, so early testing is crucial for high-risk patients.

Why Choose MedGenome For Your Febrile Neutropenia Testing?

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