HRR Track Test

Detects mutations in homologous recombination repair genes including BRCA1 and BRCA2

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What is HRR Track Test?

The HRR Track Test is an advanced genetic screening tool designed to detect mutations in Homologous Recombination Repair (HRR) genes, which play a crucial role in DNA damage repair. Deficiencies in HRR pathways are linked to various cancers, including ovarian, breast, prostate, and pancreatic cancers, making them key biomarkers for treatment decisions. This test utilises Next-Generation Sequencing (NGS) to analyse a panel of HRR-related genes, helping clinicians assess a patient’s eligibility for PARP inhibitor therapies and other targeted treatments. By identifying HRR mutations, the HRR Track Test enables personalised cancer management and guides therapeutic strategies for improved patient outcomes.

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HRR Pathway Gene List

Gene List	Gene List	Gene List
ATM	BRCA2	CHEK1
PALB2	RAD51C	BARD1
BRIP1	CHEK2	PPP2R2A
RAD51D	BRCA1	CDK12
FANCL	RAD51B	RAD54L

Clinical Applications of HRR Track Test

Predicts PARP inhibitor and platinum sensitivity.
Refines risk and response prediction.
Enables tailored and personalised treatment.
Determines eligibility for clinical trails.
Detects acquired mutations linked to treatment failure.

Specification

Indications: Breast Cancer, Ovarian Cancer, Pancreatic Cancer and Prostate Cancer.
Methodology: Next-Generation Sequencing (NGS).
Sample Type: Tissue Biopsy: FFPE Tissue blocks (Minimum of 20% tumor content; Sample should be accompanied by an HPE Report and an IHC report) Liquid Biopsy: 2* 10ml of Peripheral blood in Streck tube Germline: Bone Marrow Aspirate / Peripheral Blood in EDTA.
Accuracy: Average Depth of sequencing (Pre UMI): ≥20,000X I Average Depth of sequencing (Post UMI): ≥1000X.
Coverage: SNVs & InDels. Detects both somatic and germline variants. Complete coding regions and splice site boundaries (+ / -10 bp) are covered.

HRR Track Tests Offered by MedGenome

Homologous Recombination Repair (HRR) pathway genes (Liquid Biopsy)

Detects: 15 Homologous Recombination Repair (HRR) pathway genes including BRCA1/2.
TAT: 14 working days
Test Code: MGM2455

Germline HRR (Homologous Recombination Repair) pathway genes analysis

Detects: 15 Homologous Recombination Repair (HRR) pathway genes including BRCA1/2.
TAT: 14 working days
Test Code: MGM1881

Tumour HRR (Homologous Recombination Repair) pathway genes analysis

Detects: 15 Homologous Recombination Repair (HRR) pathway genes including BRCA1/2.
TAT: 14 working days
Test Code: MGM1623

Key Highlights of MedGenome's HRR Track Test

Comprehensive HRR Gene Analysis

Detects mutations in 15 Homologous Recombination Repair (HRR) pathway genes, including BRCA1, BRCA2.

Indications

Prostate, Ovarian, Breast and Pancreatic Cancers.

High Analytical Sensitivity & Specificity

Achieves ≥95% sensitivity and 100% specificity for SNVs and InDels, ensuring accurate variant detection.

Trusted by Healthcare Providers

MedGenome is trusted and recommended by 24,000+ clinicians and 8,000+ hospitals across India and South Asia.

What is HRR Track Test?

The HRR Track Test is a genetic test designed to detect mutations in Homologous Recombination Repair (HRR) genes, which play a crucial role in repairing damaged DNA. When these genes are faulty, the risk of certain cancers, such as ovarian, breast, pancreatic, and prostate cancer, may increase. This test helps doctors determine if a patient’s cancer is linked to HRR deficiencies and whether targeted treatments, like PARP inhibitors, could be effective.

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How is HRR Track Test Done?

Step	Description
Sample Collection	Blood sample in Streck tube.
Extraction & Sequencing	The genetic material is analysed using Next-Generation Sequencing (NGS) to detect mutations in HRR genes.
Results Interpretation	The test results help doctors determine if a patient has HRR-related mutations and whether targeted treatments are an option.

How Does HRR Track Test Work?

The HRR Track Test analyses a set of genes involved in DNA repair. It uses Next-Generation Sequencing (NGS) to identify mutations in HRR genes that may lead to cancer growth. The test also helps predict a patient’s response to targeted therapies such as PARP inhibitors, which are effective in treating HRR-deficient cancers.

Who Should Consider HRR Track Testing?

What Do HRR Track Test Results Mean?

HRR-Positive (Mutation Detected) – This indicates that mutations in HRR genes are present, which may increase cancer risk and impact treatment choices.
HRR-Negative (No Mutation Detected) – No significant mutations were found, meaning HRR-related cancer risks are lower.

How Often Should HRR Track Test Be Performed?

When Should You Get an HRR Track Testing?

Before starting treatment for HRR-related cancers (such as ovarian, breast, prostate, or pancreatic cancer).
If there is a family history of hereditary cancers and genetic testing is recommended.
When considering PARP inhibitor therapy to determine eligibility and treatment response.

Why Choose MedGenome's HRR Track Testing?

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