CMV Drug Resistance Test

Advanced NGS-based detection for targeted therapy

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What is CMV Drug Resistance Testing?

Cytomegalovirus (CMV) drug resistance testing is a next-generation sequencing (NGS)-based diagnostic test designed to detect genetic mutations in specific genes of CMV. These mutations can cause resistance to antiviral drugs, leading to treatment failure in transplant recipients, immunocompromised patients, and congenital CMV cases. By identifying resistance early, this test enables personalised antiviral therapy, optimising patient management and preventing complications associated with prolonged or ineffective treatment.

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Gene Coverage in CMV Drug Resistance Testing

Gene	Function
UL97	Encodes a viral kinase.
UL56	Encodes the terminase complex protein.
UL54	Encodes viral DNA polymerase.

Key Benefits of the CMV Drug Resistance Testing

Guides selection of effective antiviral treatment.
Reduces the risk of prolonged or ineffective therapy.
Helps in the early detection of resistance mutations.
Improves patient outcomes by optimising treatment plans.

Specifications

Test Code: MGM1803
Methodology: Next-Generation Sequencing (NGS).
Turnaround Time: 5-7 working days.
Specimen Type: Whole Blood (EDTA) and plasma. Samples should be positive by quantitative PCR (viral load 2150 copies/ml or 1250IU/ml).
Container: EDTA Tube
Volume Requirement: 3ml
Transportation Temperature: 2-8°C

Diseases & Disorders Detected by the CMV Drug Resistance Test

Applicable for Diseases

Cytomegalovirus (CMV) Infection
Congenital CMV
CMV Retinitis
CMV Pneumonia
CMV Gastroenteritis

Applicable for Disorders

Immunocompromised Conditions (e.g., post-transplant patients, HIV/AIDS)
Primary or Secondary Immunodeficiency Disorders

Key Highlights of MedGenome's CMV Drug Resistance Test

High Precision

Utilises advanced NGS technology to provide accurate and detailed genetic analysis, surpassing traditional resistance testing methods.

Essential for High-Risk Patients

Critical for transplant recipients, immunocompromised individuals, and congenital CMV cases, where early drug resistance detection is crucial for treatment success.

Comprehensive Coverage

Identifies resistance to ganciclovir, valganciclovir, foscarnet, cidofovir, and letermovir, ensuring precise drug selection.

Expansive Laboratory Network

Operates 20+ core, satellite, and partner labs across India, including Trident, PRL, and GenX Diagnostics; along with a 30,000 sq. ft state-of-the-art facility in Bengaluru.

What is CMV Drug Resistance Testing?

Cytomegalovirus (CMV) drug resistance testing is a specialised test that helps doctors determine if CMV has developed resistance to antiviral medications. CMV is a common virus that can become dangerous for transplant patients, individuals with weakened immune systems, and newborns. When CMV does not respond to standard treatments, it may indicate drug resistance. This test identifies specific genetic mutations in the virus, allowing doctors to adjust medications for effective treatment and prevent complications.

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How is CMV Drug Resistance Testing Done?

Step	Process	Details
Sample Collection	Blood or plasma sample is drawn.	A small amount of blood or plasma is collected from the patient.
Laboratory Testing	Analysis using Next-Generation Sequencing (NGS).	Detects mutations in UL97, UL54, and UL56 genes to determine drug resistance.
Results Interpretation	Review of genetic findings.	Doctors analyse the test results to check for resistance and recommend alternative antiviral therapy if needed.

How Does the CMV Drug Resistance Test Work?

The CMV drug resistance test works by analysing the genetic makeup of the virus to detect mutations that make it resistant to antiviral drugs.

Uses Next-Generation Sequencing (NGS) – A highly advanced method that examines CMV’s UL97, UL54, and UL56 genes, which are responsible for drug resistance.
Detects resistance mutations early – Helps doctors determine if standard CMV medications will be effective or if alternative treatments are needed.
Prevents treatment delays – Instead of waiting to see if a patient’s symptoms improve, this test allows doctors to quickly modify antiviral therapy for better outcomes.

Who Should Consider CMV Drug Resistance Testing?

What Do CMV Drug Resistance Test Results Mean?

No resistance detected – The virus is still responsive to standard antiviral medications, and treatment can continue as planned.
Resistance mutations identified – The virus has developed resistance to specific antiviral drugs, and doctors will recommend an alternative treatment.
Multiple resistance mutations found – The virus is resistant to several drugs, requiring a customised antiviral approach.

When Should You Get A CMV Drug Resistance Test?

Why Choose MedGenome for CMV Drug Resistance Testing?

Advanced Next-Generation Sequencing (NGS) Technology – Provides fast and precise identification of CMV resistance mutations.
Comprehensive Gene Analysis – Examines UL97, UL54, and UL56 genes, which are key to antiviral resistance.
Fast Turnaround Time – Delivers results quickly, allowing doctors to make timely treatment decisions.
Essential for High-Risk Patients – Ideal for transplant recipients, immunocompromised individuals, and newborns with CMV infections.
Trusted by Leading Hospitals and Clinicians – MedGenome follows international quality standards to ensure accurate and reliable test results.

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