Sepsis-AMR Panel

What is Sepsis-AMR Panel?

Sepsis-AMR panel by MedGenome is an advanced, qualitative RT-PCR-based test designed to aid in the rapid detection of sepsis pathogens and antibiotic-resistance genes directly from whole blood. This sepsis screening detects 22 bacterial and fungal pathogens and 8 antimicrobial resistance (AMR) genes. This testing method for sepsis, with its streamlined methodology and comprehensive pathogen detection, empowers clinicians with precise and actionable information critical for effective patient management in life-threatening sepsis cases.

Pathogen Profile for SEPSIS AMR

CategoryDetails
BacteriaGram‑positiveStaphylococcus spp., S. aureus, Streptococcus spp., S. pneumoniae, Enterococcus faecium, E. faecalis, Neisseria meningitidis, Haemophilus influenzae.
Gram‑negativePseudomonas spp., P. aeruginosa, Klebsiella pneumoniae, K. oxytoca, Acinetobacter baumannii, Listeria monocytogenes, Stenotrophomonas maltophilia, Escherichia coli, other Enterobacteriaceae.
AMR GenesvanA, vanB (vancomycin resistance); OXA‑48, KPC, NDM, VIM, IMP (carbapenem resistance); mecA/mecC (methicillin resistance).
FungiCandida krusei, C. glabrata, C. albicans, C. parapsilosis, C. tropicalis.

Clinical Applications of Sepsis-AMR Panel

  • Identifies multiple pathogens, including bacteria and fungi associated with sepsis.
  • Offers accurate pathogen detection in whole blood samples, minimising false positives and negatives.
  • Detects genes linked to antibiotic resistance, guiding effective antibiotic selection.
  • Promotes targeted antibiotic therapy, lowering the risk of resistance and improving patient outcomes.
  • Supports infection control and epidemiological tracking through rapid pathogen and resistance identification.

Specifications

  • Test Code: MG3117
  • Methodology: Multiplex qualitative RT-PCR-based test.
  • Sensitivity: 82.00%
  • Specificity: 98.30%
  • Limit of Detection (LOD): 500-1000 cfu/mL for whole blood.
  • Sample Type: Whole blood (EDTA) – 1ml minimum 2-8°C.
  • Turnaround Time (TAT): 1 working day from sample receipt.
Human DNA structure highlighting MedGenome genetic testing and DNA test in India

22 Pathogen and 8 Resistance Gene Coverage (Bacteria - 17 | AME Gene - 08 | Fungi - 05)

Key Highlights of Sepsis-AMR Panel

Simplified Diagnostic Process

Performed directly from whole blood, simplifying the diagnostic process and reducing the time from sample collection to results, crucial for critical care settings.

Certified Accuracy and Reliability

Offering a reliable and accurate diagnostic tool that meets the highest standards for patient care with CE-IVD certification.

Trusted by 24,000+ Clinicians

MedGenome is trusted and recommended by 24,000+ clinicians and 8,000+ hospitals across India and South Asia.

What is Sepsis?

Sepsis is a life-threatening condition that occurs when the body's immune system overreacts to an infection, leading to widespread inflammation, tissue damage, organ failure, and potentially death. It is triggered mostly by bacterial or fungal infections that spread into the bloodstream.

What are the Common Pathogens Associated with Sepsis?

CategoryPathogens/Genes
BacteriaGram PositiveStaphylococcus spp., Staphylococcus aureus, Streptococcus spp., Streptococcus pneumoniae, Enterococcus faecium, Enterococcus faecalis, Listeria monocytogenes.
Gram NegativeNeisseria meningitidis, Haemophilus influenzae, Pseudomonas spp., Pseudomonas aeruginosa, Klebsiella pneumoniae, Klebsiella oxytoca, Acinetobacter baumannii, Stenotrophomonas maltophilia, Escherichia coli, Enterobacteriaceae.
Antimicrobial Resistance (AMR) GenesVanA-Vancomycin resistance, VanB-Vancomycin resistance, OXA-48-Carbapenem resistance, KPC-Carbapenem resistance, NDM-Carbapenem resistance, VIM-Carbapenem resistance, IMP-Carbapenem resistance, mecA/mecC-Methicillin resistance.
FungiCandida krusei, Candida glabrata, Candida albicans, Candida parapsilosis, Candida tropicalis.
MedGenome scientist conducting genetic testing and DNA test services in India

Why is AMR Detection Important in Sepsis?

Antimicrobial resistance (AMR) occurs when bacterial or fungal infections no longer respond to the drugs designed to kill them. In sepsis cases, detecting AMR is critical for several reasons:

  • Rapid and Effective Treatment: Sepsis requires immediate treatment. Identifying drug-resistant pathogens early helps clinicians prescribe the right antimicrobials, reducing delays in treatment and avoiding empirical therapy.
  • Prevention of Treatment Failure: If patients are treated with ineffective antimicrobials due to undetected resistance, their condition can rapidly worsen, increasing mortality risk.
  • Reducing Healthcare Burden: Drug-resistant infections lead to longer hospital stays, higher medical costs, and increased use of last-resort antibiotics, which may have severe side effects.
  • Controlling the Spread of Resistance: Early AMR detection helps prevent the spread of resistant pathogens in hospitals and communities, reducing future outbreaks.

What is the Sepsis-AMR Panel?

How Does Antimicrobial Resistance (AMR) Relate to Sepsis?

MedGenome clinician reviewing patient records to support genetic testing and DNA test in India

How Can Early Identification of Sepsis Help?

Detecting sepsis early can enhance the chance of recovery and improve prognosis. Sepsis screening with tools like the sepsis-AMR panel allows doctors to identify the causative microbes early, which can:

  • Prevent organ damage by starting appropriate treatment sooner.
  • Increase the chances of survival.
  • Reduce the reliance on broad-spectrum antibiotics, lowering the risk of AMR development.
  • Optimize the care plan, improving overall patient outcomes.

What are the Implications of Delayed Treatment in Sepsis Cases?

How is Sepsis-AMR Testing Done?

MedGenome diagnostic imaging supporting advanced genetic testing and DNA test services in India

Who Should Consider Getting Tested For Sepsis?

The Sepsis-AMR Panel is suitable for:

  • Patients showing signs of sepsis, such as high fever, rapid breathing, or confusion.
  • Critically ill patients in intensive care units.
  • Those with risk factors for severe infections, like the elderly, individuals with weakened immune systems, or patients with chronic conditions.

If there is any suspicion of sepsis, early sepsis screening with this test could be lifesaving.

What Do Sepsis Panel Test Results Mean?

Why Choose Medgenome For Testing For Sepsis?

Frequently Asked Questions (FAQs)

  • How much does the sepsis-AMR panel cost in India?

    The cost of the sepsis-AMR panel may vary depending on the genetic testing provider. For competitive pricing, contact MedGenome.

  • What sample is used while testing for sepsis?

    MedGenome's sepsis screening uses whole blood samples, which are easier to manage and provide quicker results than complicated, time-consuming traditional sepsis panels.

  • How long does it take to get results from the sepsis-AMR panel?

    Typically, MedGenome’s sepsis-AMR panel results are available within a day, allowing for quick intervention in critical care settings.

  • How often should a sepsis panel be repeated in critically ill patients?

    In critically ill patients, repeat testing may be necessary if there are changes in clinical status or if new infections are suspected. Your doctor will guide the frequency of testing based on your condition.

  • How does the sepsis panel differ for adults, neonates, and burn patients?

    The sepsis panel testing is flexible and can be adapted to meet specific needs. For neonates and burn patients, testing might be customised to ensure accurate detection, considering their unique medical needs.

  • Can a negative sepsis panel result rule out sepsis completely?

    No, a negative sepsis panel does not entirely rule out sepsis. Clinical evaluation and other diagnostic methods may be needed for a comprehensive assessment.

Get Genetic Counselling by Our Experts

Connect with Our Experts

    MedGenome Patient Stories

    MedGenome in the News

    September 12, 2023 5 mins read

    NIPT for Twins: What You Should Know?

    December 30, 2021 5 mins read

    Unlocking Insights: Genetic Tests Every Woman Should Consider

    August 21, 2019 5 mins read

    A new technology for eradicating TB – MedGenome Labs – Mathrubhumi

    Please share your details to get
    in touch with our experts.