ClonoTrack is an advanced next-generation sequencing (NGS) based assay that analyzes immunoglobulin (IG) gene rearrangements to identify and characterize clonal B-cell populations with high analytical precision. By defining dominant clonal sequences at diagnosis, ClonoTrack enables highly sensitive, sequence-specific minimal residual disease (MRD) tracking across treatment and follow-up, supporting evidence-based clinical decision-making in B-cell malignancies. Accurate assessment of B-cell clonality and minimal residual disease (MRD) is critical for the diagnosis, risk stratification, and long-term monitoring of B-cell malignancies. Conventional methods such as flow cytometry and PCR may have limitations in sensitivity for very low-level disease or track clonal evolution over time.
| Feature | Description | |
|---|---|---|
| NGS-based clonality analysis | Evaluates the B-cell repertoire to distinguish polyclonal (reactive) from clonal (mono, bi-, or oligoclonal) populations. | |
| High-sensitivity MRD detection | Detects residual disease down to 10⁻⁶ sensitivity. | |
| Comprehensive IG coverage | Targets IGH (FR1, FR2, FR3) and IGK rearrangements. | |
| SHM assessment | Provides somatic hypermutation status for prognostic insights. | |
| Longitudinal monitoring | Enables serial MRD tracking using the baseline dominant clone signature. | |
| Objective quantification | Quantifies MRD burden using sequence-based cell equivalents (% reads). |
TAT: 21 working days
Test Code: MGM3659
TAT: 21 working days
Test Code: MGM3660
Enables detection of minimal residual disease with sensitivity up to 10⁻⁶, supporting early identification of molecular relapse.
Analyses IGH (FR1, FR2, FR3) and IGK rearrangements to ensure broad detection of B-cell clonal populations.
Identifies dominant clone sequences at diagnosis and uses the same molecular signature for accurate longitudinal MRD monitoring.
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