OncoTrack Liquid

What is Liquid Biopsy?

Liquid Biopsy is a minimally invasive genetic test that detects and analyses cancer-associated biomarkers from blood samples. This test is performed on the blood of the patient to evaluate tumor derived DNA (ctDNA) for molecular biomarker detection. This approach enables early cancer detection, therapeutic target identification, minimal residual disease (MRD) monitoring, assessment of disease recurrence, prediction of patient outcomes, risk stratification, and evaluation of treatment response.

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Key Liquid Biopsy NGS Assays

Test Name Details
OncoTrack CGP Comprehensive genomic profiling of solid tumors from blood | High precision
multibiomarker test | SNVs & InDels - 523 genes I CNVs - 59 genes I Fusion - 23 genes | MSI | TMB.
OncoTrack Advance 118 genes for all solid tumors detects SNVs, InDels & Fusions.
LungTrack Advance 24 genes for NSCLC (SNVs, InDels & Fusions).
OncoTrack Ultima 118 genes for all solid tumors detects SNVs & InDels.
HRR Track 15 genes involved in the homologous recombination repair pathway, including BRCA1 & BRCA2 genes.
OncoTrack Screens for the presence of oncogenic driver mutations in four key genes: EGFR, KRAS, NRAS and BRAF.
Colorectal Cancer Screen all the NCCN guided actionable biomarkers in colorectal cancer.
Minimal Residual Disease (MRD) Minimal Residual Disease (MRD) by NGS in Solid Tumors (Liquid Biopsy).

Clinical Applications of Liquid Biopsy Test

  • Patient discomfort, risk & morbidity: Tumor biopsies are often difficult to obtain and increase patient discomfort and procedural risk.
  • Quality issues with tissue: Biopsy samples may be degraded, poorly fixed or difficult (e.g., bony tissue), leading to higher assay failures compared with Liquid Biopsy.
  • Low tumour content / limited sampling: Tissue may have low tumour cellularity or be unavailable. It reflects only one site and time point, while liquid biopsy captures broader spatial and temporal heterogeneity, including metastatic sites.
  • Treatment monitoring & relapse (MRD): Enables non-invasive monitoring and early detection of relapse.
  • Acquired Resistance: Identifies resistance mutations that emerge during treatment (example: EGFR T790M or MET exome skipping mutation in NSCLC)
  • Timely treatment: Avoids delays associated with tissue biopsy and supports faster clinical decisions.

Specifications

  • Indications: Advance solid tumors, before first line therapy or at progression.
  • Methodology: Next Generation Sequencing.
  • Sample Type: Peripheral blood in Streck tube (10ml X 2).
  • Accuracy: Limit of detection: 0.2% VAF I Average depth of sequencing (Pre UMI): ≥20,000X I Average depth of sequencing (Post UMI): ≥2000X.
  • Coverage: Comprehensive coverage of complete coding regions and intron–exon boundaries of all genes for SNVs, InDels & Fusion detection.
Human DNA structure highlighting MedGenome genetic testing and DNA test in India

Liquid Biopsy Tests Offered by MedGenome

All Solid Tumors

  • Test Name: OncoTrack CGP (Liquid Biopsy)

    • Detects: SNVs & InDels – 523 genes, CNVs – 59 genes, Fusion – 23 genes, MSI and TMB
    • TAT: 21 working days
    • Test Code: MGM3309

  • Test Name: Oncotrack Advance - Liquid Biopsy NGS Test (SNVs, InDels and Fusions)

    • Detects: SNVs and InDels in 118 genes and Fusion in 15 genes
    • TAT: 14 working days
    • Test Code: MGM2718

  • Test Name: Oncotrack Ultima - Liquid Biopsy Test by NGS (SNVs & InDels)

    • Detects: SNVs and InDels in 118 genes
    • TAT: 14 working days
    • Test Code: MGM455

  • Test Name: Liquid Biopsy NGS Panel (SNVs, InDels & Fusions)

    • Detects: SNVs and Indels in 33 genes and Fusion in 13 genes
    • TAT: 14 working days
    • Test Code: MGM2772

  • Test Name: Minimal Residual Disease (MRD) by NGS in Solid Tumours (Liquid Biopsy)

    • Detects: No of genes covered: 118
    • TAT: 14 working days
    • Test Code: MGM2649

Lung Cancer

  • Test Name: LungTrack Advance – Liquid Biopsy Test by NGS (SNVs, InDels & Fusions)

    • Detects: SNVs and InDels in 24 genes and Fusion in 12 genes
    • TAT: 14 working days
    • Test Code: MGM2623

  • Test Name: Lung Cancer Panel (16 Genes) – Liquid Biopsy

    • Detects: SNVs and InDels in 16 genes and Fusion in 9 genes
    • TAT: 14 working days
    • Test Code: MGM3213

  • Test Name: OncoFocus – Liquid Biopsy NGS Test for EGFR Gene Mutations

    • Detects: EGFR gene mutation
    • TAT: 12 working days
    • Test Code: MGM481

  • Test Name: OncoSelect – Liquid Biopsy NGS Test for EGFR TKI Resistance

    • Detect: EGFR (T790M and C797S)
    • TAT: 12 working days
    • Test Code: MGM420

Colorectal Cancer

  • Test Name: Colorectal Cancer Panel (Liquid Biopsy)

    • Detect: SNVs & InDels in 9 key genes
    • TAT: 14 working days
    • Test Code: MGM3197

HRR Genes Liquid Biopsy Panel : (Breast, Ovarian, Prostate and Pancreatic Cancer)

  • Test Name: Liquid Biopsy NGS Test (SNVs and InDels)

    • -15 Homologous Recombination Repair
    • (HRR) pathway genes, including BRCA1/2
    • TAT: 14 working days
    • Test Code: MGM2455

Breast Cancer

  • Test Name: Advanced Breast Cancer Gene Panel

    • TAT: 14 working days
    • Test Code: MGM3328

  • Test Name: ESR1 Gene Testing by NGS -Liquid Biopsy (HotSpot Mutations)

    • Detects: ESR1
    • TAT: 14 working days
    • Test Code: MGM2732

  • Test Name: PIK3CA – Therascreen® – Liquid Biopsy

    • TAT:  6 working days
    • Test Code: MGM1678

  • Test Name: PIK3CA Gene Mutation Analysis by NGS – Liquid Biopsy

    • TAT: 14 working days
    • Test Code: MGM1677

Key Advantages of MedGenome's Liquid Biopsy Test

Comprehensive Coverage

Complete coding regions of all the genes and intron/exon boundaries for SNVs, InDels & Fusion detection.

Minimally Invasive

Leverages minimally invasive blood samples as a complement to tissue biopsy or as an alternative when tissue is not readily available.

Variant Calling

Sophisticated variant calling algorithms and high depth of sequencing enable detection of key biomarkers in cfDNA with MGM3309 - 0.5%. Rest of the Liquid Biopsy 0.2% Limit of Detection (LOD).

What is Liquid Biopsy?

A Liquid Biopsy is a simple blood test used to check for signs of cancer. It looks for cancer-related markers, such as tiny fragments of tumor DNA (cfDNA) or circulating tumor cells, in the blood. Unlike traditional biopsies, which require surgery to obtain a tissue sample, a Liquid Biopsy is a quick, safe, and minimally invasive alternative that doesn’t require surgical intervention. This test can help doctors monitor cancer progression, evaluate how well a treatment is working, detect potential resistance to therapy, and gain insights into the genetic makeup of the tumor to guide personalised treatment decisions.

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How is a Liquid Biopsy Different From a Tissue Biopsy?

Feature Liquid Biopsy Tissue Biopsy
Invasiveness Minimally invasive (blood sample). Invasive (surgical procedure required).
Sample Type Analysis of cell-free DNA to be retained. Analyses physical tumour tissue.
Monitoring Helps track how cancer is growing or responding to treatment. Shows the condition of the tumor at one point in time.
Turnaround Time Generally faster results. Longer processing time.
These differences emphasise the benefits of liquid biopsy in cancer diagnostics and monitoring.
MedGenome scientist conducting genetic testing and DNA test services in India

Why Choose Liquid Biopsy Testing?

Liquid Biopsy Testing offers several significant benefits in cancer diagnostics.

  • First, It is minimally invasive, requiring only a blood sample, which enhances patient comfort compared to traditional tissue biopsies.
  • It analyses components like cell-free DNA (cfDNA), giving a detailed picture of the tumor’s genetic makeup.
  • Additionally, Liquid Biopsy enables real-time monitoring of tumour evolution and treatment response, providing timely insights that can guide therapy adjustments.
  • Results are quicker, making it a good choice for ongoing cancer care.

Overall, Liquid Biopsy in cancer represents a powerful screening test for personalised treatment strategies.

What Are the Types of Liquid Biopsy Techniques?

MedGenome clinician reviewing patient records to support genetic testing and DNA test in India

How Does a Liquid Biopsy Test Work?

A liquid Biopsy is a cutting-edge blood test used to detect and monitor cancer. It’s a quick, simple, and non-invasive alternative to traditional tissue biopsies.

When someone has cancer, tiny traces of the tumor—such as cancer cells (circulating tumor cells or CTCs) and fragments of tumor DNA (circulating tumor DNA or ctDNA)—can be released into the bloodstream. A liquid biopsy analyses these components to:

  • Detect cancer early.
  • Understand the genetic makeup of the tumor.
  • Identify possible treatment options.
  • Track how well the treatment is working.
  • Monitor for signs of the cancer returning.

Because it only requires a blood sample, this test can be done more frequently to give real-time insights into your condition, helping your care team make informed decisions quickly and safely.

Liquid biopsy is an important tool in personalised cancer care, offering hope for better outcomes with fewer procedures.

How is a Liquid Biopsy Test Done?

Who Should Consider the Liquid Biopsy Test?

MedGenome diagnostic imaging supporting advanced genetic testing and DNA test services in India

What Does Liquid Biopsy Test Results Mean?

The Liquid Biopsy Test results provide insights into the existence of circulating tumor cells (CTCs) or cell-free DNA (cfDNA) in the bloodstream.

  • A positive result means cancer cells or DNA were found in your blood, and you may need more tests or treatments.
  • A negative result means no cancer markers were found, but it doesn’t always mean you are cancer-free.

Understanding these results is crucial for determining the appropriate next steps in cancer management. Discuss your results with a doctor for comprehensive interpretation. For more details, contact MedGenome.

Can Liquid Biopsy Screen For All Cancers?

Why Choose MedGenome For Your Liquid Biopsy Testing?

FAQs

  • How much does the Liquid Biopsy test cost in India?

    The Liquid Biopsy test price in India can vary depending on the provider and the specific analysis performed. Factors such as the number of cancer markers analysed and the technology used can influence the overall cost. To find the best rates, get in touch with MedGenome for a personalised quote.

  • How accurate are Liquid Biopsies in detecting cancer?

    Liquid Biopsies are highly accurate in cancer detection, especially for monitoring mutations and tumor progression. While they are less invasive than tissue biopsy, sensitivity may vary depending on cancer type and stage.

  • How often can Liquid Biopsies be performed?

    Due to their non-invasive nature, Liquid Biopsy tests can be performed frequently. The intervals depend on clinical needs, such as tracking cancer progression or treatment response. Regular Liquid Biopsy Testing offers real-time monitoring without the risks associated with traditional biopsies.

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