KaryoTrack - Chromosomal Microarray Test

Detecting chromosomal abnormalities with precision

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What is KaryoTrack?

KaryoTrack is an advanced chromosomal analysis test designed to detect numerical and structural abnormalities in chromosomes. Utilising high-resolution genomic technology, it identifies aneuploidies, deletions, duplications, and translocations, making it essential for diagnosing genetic disorders, recurrent pregnancy loss, infertility, and congenital anomalies. The test is particularly valuable in prenatal screening, fertility assessments, and genetic counselling. KaryoTrack provides rapid, high-precision results, aiding clinicians in making informed medical and reproductive decisions for personalised patient care.

KaryoTrack offers broad clinical coverage across multiple disease areas, including neurological, oncological, cardiovascular, endocrine and metabolic, haematological, and newborn conditions, among others. It is cost-effective, suitable for both prenatal and postnatal samples, and detects 700K genome-wide probes, including CNVs, ROHs, mosaicism, UPD, and polyploidy.

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Key Features of KaryoTrack

Accurate detection of copy number variants (CNVs), loss of heterozygosity (LOH), mosaicism, uniparental disomy (UPD), and polyploidy.
Covers over 4,800 cytogenetic-related key genes across the genome for comprehensive analysis.
Optimised for broad applications, delivering high-quality and reproducible data.
Includes ~700K markers for high exonic coverage, ensuring precise copy number variation (CNV) calls and high-resolution target region analysis.
Uses a proprietary database (~15,000 entries) and research-backed annotations to support variant ranking.
Compliant with ACMG (American College of Medical Genetics and Genomics) guidelines, ensuring high diagnostic accuracy.

Specifications

Methodology: SNP array-based testing.
Sample Types: Chorionic villus sampling (CVS) / amniotic fluid (AF) / cultured amniotic fluid / cord blood / cardiac blood / products of conception tissue (POC) / peripheral blood / direct DNA / DNA isolated from cell lines or cultured cells.
Markers Analysed: ~700K.
Detection Capabilities: Copy number variations (CNVs), loss of heterozygosity (LOH), uniparental disomy (UPD), mosaicism, polyploidy.
Resolution Target: ~10 Kb.
Detection Sensitivity: Identifies CNVs from 12.5 Kb to whole chromosomal aberrations.
Spacing on Tiers (Avg/Median): ~2 Kb / ~1 Kb.
% Well-Covered Tired Exons: ~98%.

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KaryoTrack Test Details

KaryoTrack

Methodology : Chromosomal Microarray (CMA)
TAT : 14 working days
Test Code: MGM2741

KaryoTrack with Prenatal Cell Culture

Methodology : Chromosomal Microarray (CMA)
TAT: 21 working days
Test Code: MGM2758

Key Highlights of MedGenome's KaryoTrack Test

Cost-Effective Solution

Provides an affordable yet highly accurate chromosomal analysis for genetic disorders.

Applicable for Prenatal & Postnatal Testing

Suitable for analysing both fetal and postnatal genetic conditions, making it versatile for clinical use.

Detects Multiple Genetic Variations

Identifies Copy Number Variations (CNVs), Regions of Homozygosity (ROHs), Mosaicism, Uniparental Disomy (UPD), and Polyploidy with precision.

Trusted by 24,000+ Clinicians

MedGenome is trusted and recommended by 24,000+ clinicians and 8,000+ hospitals across India and South Asia.

Highest Standard

Compliant with ACMG (American College of Medical Genetics and Genomics) guidelines, ensuring high diagnostic accuracy.

What is KaryoTrack?

KaryoTrack is a specialised genetic test that analyses chromosomal abnormalities to help detect conditions that may cause developmental disorders, miscarriages, or genetic diseases. This test examines the structure and number of chromosomes in a person’s DNA, helping doctors diagnose conditions linked to missing, extra, or rearranged chromosomes. It is commonly used in prenatal testing, fertility evaluations, and genetic disorder diagnosis, ensuring timely medical intervention and personalised treatment planning.

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How Is the KaryoTrack Test Done?

Step	Process	Details
Sample Collection	Blood, amniotic fluid, or tissue sample is taken.	A doctor collects a blood sample (or amniotic fluid in prenatal cases) based on the medical requirement.
Chromosome Analysis	Laboratory testing using genetic techniques.	The sample is analysed to detect missing, extra, or altered chromosomes that could indicate genetic disorders.
Results Interpretation	Genetic specialist evaluates findings.	The doctor reviews the test results to check for chromosomal abnormalities affecting health or fertility.

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How Does KaryoTrack Test Work?

The KaryoTrack test works by studying a person’s chromosomes (DNA structures) to look for abnormalities.

Uses advanced genomic technology to provide a detailed chromosome analysis.
Detects missing, extra, or altered chromosomes, which can cause genetic disorders.
Helps in diagnosing conditions like Down syndrome, Turner syndrome, and other chromosomal abnormalities.
Aids in fertility assessments by detecting genetic reasons for miscarriages or failed pregnancies.

Who Should Consider KaryoTrack Testing?

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What Do KaryoTrack Test Results Mean?

Normal Result: No chromosomal abnormalities detected, meaning there are no structural or numerical issues in the tested sample.
Abnormal Result: A chromosomal disorder is detected, which may indicate a condition like Down syndrome, Turner syndrome, or other genetic issues.
Variant of Uncertain Significance (VUS): A change is found, but its impact is not clearly understood, requiring further analysis.

How Often Should the KaryoTrack Test Be Performed?

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When Should One Get a KaryoTrack Test?

One should consider the KaryoTrack test if they:

Have a history of multiple miscarriages or pregnancy complications.
Are pregnant and have abnormal ultrasound findings suggesting chromosomal issues.
Have a child or family member with a known genetic disorder and need genetic confirmation.
Experience unexplained infertility and want to rule out chromosomal abnormalities.
Are planning to start a family and want to check for inherited chromosomal risks.

Early detection through this test helps in family planning, medical management, and informed reproductive decisions.

Why Choose MedGenome's KaryoTrack?

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