Alzheimer’s Disease Bio-Marker Panel

What is the Alzheimer’s Disease Bio-Marker Panel?

The Alzheimer’s Disease Bio-Marker Panel is a blood-based biomarker test that assesses plasma p-tau217 and β-Amyloid 1-42, integrating these two pathological signals into a p-tau217/β-Amyloid 1-42 plasma ratio.
Alzheimer’s disease is a biological process involving amyloid and tau pathology, while cognitive symptoms alone may not always reveal the underlying pathology.
The panel provides a proactive, biology-driven approach to Alzheimer’s disease assessment, bringing biological evidence closer to clinical decision-making.

Clinical Utility of the Alzheimer’s Disease Bio-Marker Panel

Parameter Details
Biomarkers Analysed p-tau217 & β-Amyloid 1-42
Integrated Measure p-tau217/β-Amyloid 1-42 Plasma Ratio
Clinical Utility Biology-focused assessment of Alzheimer’s disease
Sample Type EDTA Plasma
Methodology CLIA

Clinical Applications of the Alzheimer’s Disease Bio-Marker Panel

  • Early Assessment- Provides earlier biological evidence of Alzheimer’s disease pathology, supporting assessment beyond cognitive symptoms.
  • Differential Diagnosis- Helps link clinical symptoms with underlying Alzheimer’s disease-related pathology.
  • Screening & Monitoring- Provides a convenient blood-based assessment of amyloid and tau-related biological signals.
  • Therapeutic Pathways- Supports evaluation for disease-modifying therapies by providing biology-focused information relevant to Alzheimer’s disease assessment.

Specifications

  • Methodology: CLIA
  • Clinical Significance: Biology-focused assessment of Alzheimer’s disease pathology
  • Sample Type: EDTA Plasma
  • Turnaround Time: 4 working Days
Human DNA structure highlighting MedGenome genetic testing and DNA test in India

Alzheimer’s Disease Bio-Marker Panel Offered by MedGenome

Key Highlights of MedGenome's Alzheimer’s Disease Bio-Marker Panel

Biology-Focused

Looks beyond cognitive symptoms to assess biological signals associated with Alzheimer’s disease.

Multi-Biomarker

Assesses both amyloid and tau signals.

Ratio-Based

Integrates the two biomarkers into one plasma signal.

What is the Alzheimer’s Disease Bio-Marker Panel?

Alzheimer’s disease is more than changes in memory or thinking. It is a biological process involving amyloid and tau pathology.
Sometimes, cognitive symptoms alone may not reveal what is happening biologically.
The Alzheimer’s Disease Bio-Marker Panel is a blood-based test that looks at two important biological signals: p-tau217 + β-Amyloid 1-42
The results are combined into a plasma ratio to provide biology-focused information related to Alzheimer’s disease.

MedGenome scientist conducting genetic testing and DNA test services in India

Why is This Test Important?

Look Beyond Symptoms

Memory and cognitive symptoms may not always show the complete biological picture.

Look at Two Biological Signals

The test assesses both amyloid and tau-related biomarkers.

Get a Blood-Based Assessment

The test uses an EDTA plasma sample, providing a convenient blood-based approach.

Bring Biology Closer to Clinical Decisions

The result provides additional biological information that can support your healthcare provider’s assessment.

What Does the Test Measure?

How Does the Test Work?

MedGenome clinician reviewing patient records to support genetic testing and DNA test in India

What Can the Result Add?

Biology-Focused Insight- Looks beyond cognitive symptoms.

Multi-Biomarker Assessment- Assesses both amyloid and tau signals.

Integrated Result- Combines both biomarkers into a single plasma ratio.

Blood-Based Assessment- Provides a blood-based approach to assessing Alzheimer’s disease-related biological signals.

Evidence-Backed Approach- The panel has been validated in multiple studies.

When This Test Should Be Considered?

MedGenome diagnostic imaging supporting advanced genetic testing and DNA test services in India

What Does the Evidence Show?

The 2025 Alzheimer’s Association Clinical Practice Guideline states that blood biomarkers with ≥90% sensitivity and ≥90% specificity may be used as confirmatory tests in appropriate clinical settings.

Multicenter Validation Study

97.6% Sensitivity
90.8% Specificity
91.8% PPV
97.3% NPV

Moghekar et al., Alzheimer’s & Dementia, 2026

Why Choose MedGenome for Alzheimer’s Disease Bio-Marker Testing?

FAQs

  • Why is a blood-based biomarker test useful in Alzheimer’s disease?

    Cognitive symptoms alone may not always reveal the underlying pathology. Blood-based biomarkers can provide additional biological information related to amyloid and tau pathology.

  • What biomarkers are assessed in this panel?

    The panel assesses p-tau217 and β-Amyloid 1-42 and integrates them into a p-tau217/β-Amyloid 1-42 plasma ratio.

  • Why is the ratio important?

    The ratio integrates amyloid and tau signals into one plasma signal, providing a biology-focused assessment aligned with Alzheimer’s disease pathology.

  • What does the test result add to clinical assessment?

    The result provides biology-focused information beyond cognitive symptoms and may support early assessment, differential diagnosis, screening and monitoring, and evaluation for therapeutic pathways.

  • What evidence supports the performance of this panel?

    A multicenter validation study demonstrated 97.6% sensitivity, 90.8% specificity, 91.8% PPV and 97.3% NPV for the plasma p-tau217/β-Amyloid 1-42 ratio. Moghekar et al., Alzheimer’s & Dementia, 2026.

Get Genetic Counselling by Our Experts

Connect with Our Experts

    MedGenome Patient Stories

    Please share your details to get
    in touch with our experts.