A hallmark of this AACR immunology series is the integration of several sub-disciplines of cancer immunology and immunotherapy, with a broad focus on strategies to harness the immune system for the treatment and prevention of different cancers. Leaders in the field will present their latest work and provide critical updates on our deepening understanding of the immune response towards cancer. This Special Conference will also provide a unique opportunity for the authors of highly rated abstracts to present their work to an audience of researchers from around the world. Ample time will be provided for the stimulating discussions that are necessary to further the scientific and translational goals of the field. As the sixth in the series, this conference will continue to provide a forum for the effective exchange of ideas between basic cancer immunologists, non-immunologists and clinical oncologists, from academia to industry.