What is Gastrointestinal Pathogen Panel?

Gastrointestinal Pathogen Panel

Gastrointestinal Pathogen Panel is a qualitative multiplex PCR-based test to detect and differentiate 9 species/groups of bacteria, 4 parasites and 5 viruses that can all cause gastroenteritis in humans.

Gastrointestinal Pathogen Panel

Prevalence

Gastrointestinal disease
  • Gastrointestinal disease is a major cause of morbidity and mortality worldwide, especially among young children and immunocompromised patients
  • According to WHO, globally, there are nearly 1.7 billion cases of childhood diarrhoeal disease each year and it kills around 525,000 children under five every year
  • Gastroenteritis is a common condition that affects the gut. It refers to the inflammation of the gastrointestinal tract that includes the stomach and the intestines

Why do you need this test?

  • The conventional tests includes stool culture, microscopy for ova and parasite, ELISA and rapid lateral flow test that can only test one to a few bacterial pathogens per test and takes anywhere between 30 mins to 3 days
  • Whereas Multiplex Real time PCR (Gastrointestinal Pathogen Panel) can test multiple pathogen & virluence genes per test in less than 5 hours
  • Nucleic acid amplification tests (NAATs) for enteric pathogens allow for the syndromic testing of stool for multiple pathogens simultaneously. It is rapid and accurate method
MethodsTests forTurnaround Time
Conventional techniques
Stool CultureOne to a few bacterial pathogens per test2-3 days
Microscopy for Ova and ParasiteOnly Parasitic pathogensMultiple specimens to be collected for several days for final diagnosis
ELISA (Antigen & Antibody test)Single pathogen per test6-24 hours
Rapid lateral flow testSingle pathogen per test20-30 mins
Molecular techniques
Single Plex PCRSingle pathogen per testNA
Multiplex Real time PCRMultiple pathogen & virulence genes per testLess than 2 days
BacteriaParasitesViruses
Campylobacter sppEntamoeba histolyticaNorovirus (GI/GII/GIV)
Salmonella spp.Giardia lambliaRotavirus (A)
Yersinia enterocoliticaCryptosporidium spp.Adenovirus (40/41)
Clostridium difficile toxin ADientamoeba fragilisAstrovirus
Clostridium difficile toxin BSapovirus (GI/GII/GIV/GV)
Shiga toxin producing E. coli (STEC), stx1/stx2
Enteropathogenic E. coli (EPEC), eae
Enterotoxigenic E. coli (ETEC), elt/est
Shigella/enteroinvasive E. coli (EIEC), ipaH

Advantages

Gastrointestinal Pathogen Panel
  • Detects 18 different pathogens in a single tube unlike Seegene Allplex™ Gastrointestinal Panel Assays which have separate panels for bacteria, virus and parasite.
  • Fresh or frozen stool specimens can be used, wherein pre-treatment of stool is optional and transport media is not required.
  • Extensively validated with potentially cross-reactive pathogens.
  • Internal validation at MedGenome demonstrated 100% sensitivity and specificity.
  • Robust identification of co-infections which is very common in gastrointestinal pathogens.

Who needs to get tested?

Individuals with:
  • Diarrhoea with fever, severe abdominal cramps, or signs of sepsis
  • Moderate to severe disease
  • High risk of spreading disease to others and during known or suspected outbreaks
  • Presenting with Dysentery
  • Symptoms lasting more than seven days
  • Immunocompromised patients with diarrhoea

Why MedGenome?

MedGenome offers the most comprehensive and advanced genetic and molecular tests for infectious diseases. Gastrointestinal Pathogen Panel is a qualitative multiplex PCR-based test to detect and differentiate within 2 ½ hours 9 species/groups of bacteria, 4 parasites and 5 viruses that can all cause gastroenteritis in humans (table 2). It is a CE-IVD real-time PCR-based assay.

MedGenome OffersTest CodeTest Sample requirementsTAT
Gastrointestinal Pathogen PanelMGM1728Stool
2 Working days
Post sample receipt
at the lab

Additional Information

  • Collect stool (pea sized or 2ml of unformed stool) in sterile wide mouth container.
  • Avoid contaminating the stool with urine and water.
  • If not processed immediately, the specimens should be stored at 4 °C and transported at the same temperature.
  • If specimens cannot be processed within 48 hours, they should be kept frozen at or below -20°C, preferably -70°C then transported at the same temperature.

Brochures

Gastrointestinal Infections

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