Polygenic Risk Score Test: Predictive Power Over 14 Years

Patient information

A 14-year-old female had heart attack/MI and underwent anterior wall Myocardial Infarction on 06.10.2020. She is currently on antiplatelet, statins and heparin medication. She was suggested to undergo Coronary Artery Disease -Polygenic Risk Score Test to find out whether she was at high risk of getting Coronary Artery Disease.

Genetic History

No history of heart disease, hypertension and hypercholesterolemia in the family.

Genetic testing at MedGenome

Coronary Artery Disease -Polygenic Risk Score Testing was done at MedGenome.

Result

The person has a PRS of 1.43 (blue dotted line), which indicates a population high polygenic risk, with an odds ratio of 2.43 relative to MedGenome’s cohort.

Result

Case Discussion

The Coronary Artery Disease – Polygenic Risk Score (CAD-PRS) for the person was found to be 1.43. This score has been profiled as a high risk as observed in MedGenome’s study cohort of South Asian ancestry. The person carries a high polygenic risk of getting CAD, with an OR of 2.43, based on MedGenome’s study cohort. Thus the CAD PRS test can accurately predict the risk of CAD in very young patients.