Comprehensive Thyroid Tumour Testing with ThyroTrack

    What is ThyroTrack by MedGenome Labs?

    ThyroTrack is a next-generation sequencing (NGS)--based thyroid tumour test designed to detect genomic biomarkers in thyroid nodules. This thyroid tumour testing uses FNAC (Fine Needle Aspiration Cytology) fluid and FFPE (Formalin-Fixed Paraffin-Embedded) tissue blocks to provide insights into thyroid nodule genetics. This helps in achieving diagnostic accuracy, effective clinical management, and precise surgical decisions.

    Limit of Detection (LOD) for Liquid Biopsy Assays

    Alteration TypeAnalytical Sensitivity #& Specifivity##Limit of Detection (LOD) 30ng
    SNVs*≥95%100%>0.2 AF%
    INDELs*≥95%100%>0.2 AF%
    Fusions**≥95%100%≥3 Reads
    *Tested on cfDNA reference standards **Tested on Lung track advance
    • #Analytical Sensitivity: Defined as the Detection Rate for variants present at or above the limit of detection (LoD).
    • ##Analytical Specificity: Defined as 1 minus the per-sample false positive rate.

    Which Patients May Benefit from Liquid Biopsy Test?

    Existing biopsy material is compromised, either damaged or poorly preserved.

    • The tumour content in the biopsy sample is insufficient for analysis.
    • No viable tumour tissue is available for a traditional biopsy.
    • The patient’s clinical condition does not allow for invasive procedures

    Disclaimer:

    Liquid biopsy is an investigational screening test and is not intended for primary diagnosis. It does not replace the need for a conventional tissue biopsy.

    Specifications

    • Test Code | Test Name: MGM2538 | ThyroTrack
    • Methodology NGS
    • TAT: 14 Working Days
    • Sample Requirements FNAC Fluid in RNAlater; Tissue in RNAlater; FFPE tissue block
    • FFPE Block Requirement* Cross-sectional tumour area of 25mm² containing at least 40 µm of tumour
    • Tumour Purity Minimum: 20%
    • Limit of Detection: 5% VAF* for SNVs and InDels, 10 spanning reads for fusions

    Enhanced Diagnostic Capabilities of Liquid Biopsy Tests

    Key Highlights of MedGenome Labs ThyroTrack Thyroid Tumour Testing

    Rapid Turnaround Time

    Provides results of thyroid cancer screening within 14 working days, facilitating timely clinical decisions

    Broad Application

    Suitable for use in various clinical scenarios, including pre-surgical and post-surgical evaluation.

    Mutation Profiling

    Effective in profiling mutations in thyroid nodules with indeterminate cytology, aiding in clearer clinical decision-making.

    What is ThyroTrack by MedGenome Labs?

    ThyroTrack is an advanced test for detecting risk of cancer in the thyroid nodule. It looks for specific genetic changes that may lead to the development of cancerrelated to thyroid nodules and cancer. Unlike regular thyroid tests that measure hormone levels, ThyroTrack examines the genetic details of the tumour. This helps doctors understand the tumour better and decide on the best treatment or surgery options for the patient.

    Limit of Detection (LOD) for Liquid Biopsy Assays

    Alteration TypeAnalytical Sensitivity# & Specifivity##Limit of Detection (LOD) 30ng
    SNVs*≥95%100%>0.2 AF%
    INDELs*≥95%100%>0.2 AF%
    Fusions**≥95%100%≥3 Reads
    *Tested on cfDNA reference standards **Tested on Lung track advance
    • #Analytical Sensitivity: Defined as the Detection Rate for variants present at or above the limit of detection (LoD).
    • ##Analytical Specificity: Defined as 1 minus the per-sample false positive rate.
    How Does the ThyroTrack Test Differ from Traditional Thyroid Function Tests?

    Traditional thyroid function tests measure hormones such as TSH, T3, and T4 to assess thyroid gland activity. While these tests are useful for evaluating general thyroid health, they cannot detect genetic changes in thyroid nodules or tumours.

    ThyroTrack, on the other hand, uses advanced genetic sequencing to detect specific genetic changes in thyroid nodules. This makes it a powerful tool for:

    • Differentiating between cancerous and non-cancerous thyroid nodules
    • Identifying the risk of cancer recurrence.
    • Guiding surgical and treatment decisions
    Why Do You Need the ThyroTrack Test?
    How Does the ThyroTrack Test Help in Differentiating Between Benign and Malignant Thyroid Nodules?
    How Does Liquid Biopsy Test Work?
    A liquid biopsy test detects cancer by analysing blood for circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA). Tumors release these cells and DNA fragments into the bloodstream. These components are analysed using advanced techniques to identify genetic mutations, tumour characteristics, and potential treatment responses. This non-invasive approach allows for real-time monitoring of cancer progression and therapy effectiveness, making liquid biopsy a valuable tool in modern oncology.
    How is a Liquid Biopsy Test Done?
    Who Should Consider Liquid Biopsy Test?
    What Does Liquid Biopsy Test Results Mean?

    he liquid biopsy test results provide insights into the existence of circulating tumour cells (CTCs) or cell-free DNA (cfDNA) in the bloodstream.

    • A positive result may indicate the presence of cancer, necessitating further investigation or treatment options.
    • Conversely, a negative result can suggest the absence of detectable tumour markers, though it does not rule out cancer entirely.

    Understanding these results is crucial for determining the appropriate next steps in cancer management. Discuss your results with a doctor for comprehensive interpretation. For more details, visit MedGenome.

    Can Liquid Biopsy Screen For All Cancers?
    Why Choose MedGenome Labs For Your Liquid Biopsy Testing?

    Frequently Asked Question

    • How much does the liquid biopsy test cost in India?

      The liquid biopsy test price in India typically ranges between INR 20,000 and 60,000. A liquid biopsy is a non-invasive procedure for detecting circulating tumor cells and DNA in the blood, and the liquid biopsy cost varies based on the number of cancer markers analyzed.

    • How accurate are liquid biopsies in detecting cancer?

      The liquid biopsy test price in India typically ranges between INR 20,000 and 60,000. A liquid biopsy is a non-invasive procedure for detecting circulating tumor cells and DNA in the blood, and the liquid biopsy cost varies based on the number of cancer markers analyzed.

    • How often can liquid biopsies be performed?

      The liquid biopsy test price in India typically ranges between INR 20,000 and 60,000. A liquid biopsy is a non-invasive procedure for detecting circulating tumor cells and DNA in the blood, and the liquid biopsy cost varies based on the number of cancer markers analyzed.

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